Now the smallest particles of matter cohere by the strongest attractions, and compose bigger particles of weaker virtue; and many of these may cohere and compose bigger particles whose virtue is still weaker, and so on for diverse successions, until the progression ends in the biggest particles on which the operations in chemistry, and the colours of natural bodies depend, and which by cohering compose bodies of a sensible magnitude. There are therefore agents in nature able to make the particles of bodies stick together by very strong attractions. And it is the business of experimental philosophy to find them out.

— Isaac Newton – Opticks (1704)